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Concomitant use of aspirinor other nonsteroidal anti-inflammatory agentsand corticosteroids increases the risk of gastrointestinal side effectsAspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemiaThe clearance of salicylates may be increased with concurrent use of corticosteroids.

Metabolic clearance of corticosteroids is decreased in hypothyroid patients and increased in hyperthyroid patientsChanges in thyroid status of the patient may necessitate adjustment in dosage.

When corticosteroids are administered concomitantly with potassium-depleting agentse.gamphotericin Bdiureticspatients should be observed closely for development of hypokalemiaIn additionthere have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure.

If the patient is a childit is important that the doctor monitors growth and development at intervals during treatment.

Neurological/PsychiatricConvulsionsdepressionemotional instabilityeuphoriaheadacheincreased intracranial pressure with papilledemapseudotumor cerebriusually following discontinuation of treatmentinsomniamood swingsneuritisneuropathyparesthesiapersonality changespsychic disordersvertigo.

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