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The risk of GI bleedingulceration or perforation is higher with increasing NSAID dosesin patients with a history of ulcerparticularly if complicated with haemorrhage or perforationsee section 4.3and in the elderlyThese patients should commence treatment on the lowest dose availableCombination therapy with protective agentse.gmisoprostol or proton pump inhibitorsshould be considered for these patientsand also for patients requiring concomitant low dose aspirinor other drugs likely to increase gastrointestinal risksee below and section 4.5)

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs affect each person differentlywe cannot guarantee that this information includes all possible side effectsThis information is not a substitute for medical adviceAlways discuss possible side effects with a healthcare provider who knows your medical history.

Drugs which inhibit prostaglandin biosynthesis may cause dystocia and delayed parturition as evidenced by studies in pregnant animals.

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