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Transporting medicines

drug transfer. Illustration: depositphotos.com

Development of the Technion will allow the creation of cells and tissues deep in the body in a non-invasive way with the help of ultrasound

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The applicability of the new technology is demonstrated in the contexts of local cell transplantation, drug transport for controlled local release over time and 3D bioprinting. The mechanical properties of the scaffolds can be adjusted according to the target tissue and the desired drug release rate
The new material 595R developed by the Technion researchers (on the left) alongside the stabilizing materials accepted in the industry. It can be seen that only in 595R the homogeneity of the liquid is maintained over time and the drug particles do not sink. Photo: Sharon Tzur, Technion Spokesperson

Robotic chemistry: a significant step on the way to nanoscale medicine

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In the Faculty of Biomedical Engineering at the Technion, an automatic system was developed to create a "nanometric package" for sending drugs to cancer centers in the body
Illustration image: selective capture of bacteria, their transport and electroporation (red fluorescent marker) using a Janus particle used as a mobile electrode under the application of an electric field. Prof. Gilad Yosiphon, Technion

Researchers at the Technion have developed a technology for introducing molecules into individual cells in an efficient and targeted manner

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Artist's rendering of a macroring binding to a target protein (image courtesy: University of Basel, Basilius Sauter | CC BY-SA 3.0)

Learning from nature - new substances for use as medicines

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In the figure: three possible strategies for building balls from pentagonal tiles. From left to right: a - tiles that are glued to each other directly, b - tiles that are connected using linear connectors, c - tiles that are connected using triangular connectors. Prof. Ehud Kinan and Dr. Efrat Solel. The Technion

The artificial virus

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The preparation of the platform (polymeric micelles) for transporting the tyrosine kinase inhibitor, marked with blue spheres. Illustration: Prof. Alejandro Sosnik, and Alex Bookchin. The Technion

A nanometer system for transporting drugs to treat children with cancer

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The general concept: the drug is injected into the blood system but is activated only in the selected place, using external illumination into the relevant tissue. Courtesy of the Technion spokesperson.

Light medicine: release of drugs in a precise place in the body without invasive intervention

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Cancer cells. Illustration: NIH (Yu (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC), USC Norris Comprehensive Cancer Center, Pancreatic Desmoplasia).

A new approach will allow personalized medicine for countless types of diseases

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A nanocapsule of nucleic acids and peptides that releases the medicine inside in response to defined enzymes. (1) in the first step the peptide undergoes cross-linking on the surface of the nanoparticle; (2) In the next step, a defined enzyme recognizes the peptide cross-linking group, (3) and in the last step, the enzyme's release leads to the release of the drug or the nucleic acids that were locked inside the capsule. Courtesy: Joseph Luciani/UConn.

An innovative system for delivering drugs in the body

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Nanoparticles capable of targeted delivery of drugs to cancer stem cells (yellow), those rare cells within the tumor (blue) that allow the tumor to return or spread. [Courtesy: Dipanjan Pan]

Drug-carrying nanoparticles to fight cancer cells

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A method for preparing drug carriers and their nanometric structure. The capture and release of the drug depends on the temperature surrounding the carrier system. [Courtesy: Igor Potemkin/Scientific Reports]

Nanocapsules for the precise transport of drugs

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A nanometer drug for cancer - an illustration describing the structure of the transport system and its activity in the tumor. Illustration: Maya Bar Zeev, Technion

Researchers at the Technion have developed nanometric technology for the targeted treatment of cancerous tumors in the stomach

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Whole stem cells (top left) are drained of their contents (the process is depicted in the direction of the arrow), reduced in the laboratory to nanometer size (nanometer ghosts), and loaded with nucleic acids (in blue). Those nano-ghosts are injected into the patient and through the blood vessels (in red) they reach the tumor (in green) specifically, and only there they unload their cargo, leading to the creation of the anti-cancer drug.

Cancer research: a dramatic improvement in the effectiveness of gene therapy

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Passeo-18 Lux. Illustration: Biotronics

LINC 2016: Studies Support the Use of Passeo-18 Lux as a Standard Procedure for the Treatment of Lower Extremity Arterial Occlusions

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Hunting for small molecules: the drawing depicts the experimental setup that was used to detect small molecules, such as those commonly found in drugs (green) and their binding to the receptors located on the outer surface of the cell membrane (yellow). These events can be imaged with the help of ordinary optical microscopy - subtle deformations in the structure of the cell membrane caused by the binding and dissociation of the small molecules - are translated into visible changes within the light intensity. [Courtesy: The Biodesign Institute at Arizona State University]

Small molecule sensing for drug development

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Porous silicon particles are used as a platform to transport anticancer drugs (colored in the diagram in glowing green) and release them in breast cancer tumors. The degradation of silicon in the cancerous tumor environment was studied using innovative imaging methods. The researchers followed the breakdown of the substance in the cancerous tissue and revealed its breakdown mechanism, which allows the release of drugs trapped in the porous medium.

Nanomedicine: Do cancer tumors affect drug release?

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From right to left - Ella Markovski, Prof. Ronit Sachi-Painero and Hamda Bavor-Cohen.

Researchers from Tel Aviv University have developed a nanometer drug carrier that combines two drugs for cancer tumors

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A nanogel contains a substance. Illustration: shutterstock

From electronics to nanomedicine: a unique gel developed by IBM makes it possible to deliver a cancer drug directly to the site of the tumor

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XNUMXD visualization of the drug delivery system [courtesy of the University of Melbourne].

A new coating system for the transfer of drugs

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An example of a micelle used to deliver a drug. The blue atoms are the hydrophilic end of the polymer, while the white atoms are the hydrophobic end. The red atoms symbolize the drug/active substance atoms. Such a system can also be used to transfer food materials and various additives, apart from medicines. [Source: www.atrp.gatech.edu/pt18-3/18-3_p3]

Polypid, a developer of products for the local release of drugs, raised $2.4 million in a third funding round

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Prof. Eliyahu Haldeman, Dr. Serena Greenberg and Dr. Charles Linder

Scientists at Ben-Gurion University have developed a unique drug delivery system for the brain

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Prof. Dan Farr, Tel Aviv University. Photo courtesy of him.

five year Plan

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Prof. Itai Benhar, Tel Aviv University

determination

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A polymeric nicotine trap consists of a porphyrin derivative (black) in which two amide groups (green) are attached to a zinc atom (purple) located in the center of a ring (blue). The nicotine molecule is colored red. The bottom image is a XNUMXD rendering of the polymer.

Nicotine capture polymers

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Molecules moving in a polymer network of a complex liquid experience different viscosity depending on their size. Photo - Institute of Physical Chemistry at the Polish Academy of Sciences

New insights into the viscosity of cancer cells

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